When the antisocial and lonely medical student Adam Schmidt receives a mysterious e-mail inviting him to participate of a unique medical research, he accepts the job opportunity and travels to an isolated snowing area to a cabin in the middle of nowhere. He meets Dr. Franklin Vick that kills him cutting his throat with a hunting knife. When Adam resurrects, Franklin calls him Subject Two and explains that he is engaged in an unethical medical research, bringing dead to life. Along the days, Adam is killed and resurrected over and over again, with Franklin improving his research, until the day Adam decides to leave the isolated spot.